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Prime Joint Support Formula by Isotonix

Sold by Isotonix®


Prime Joint Support Formula by Isotonix

Sold by Isotonix®


3.90 Points

Free Delivery on orders of our Exclusive Brands over £60. see details

Single Bottle (45 Servings) Code: UK13081

As the body ages, many people experience joint discomfort. Market United Kingdom understands how important it is to stay active and happy, so one option is to take a joint supplement to help promote overall bone and joint health. It is critical when...
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  • Only product on the market delivering Glucosamine, Pycnogenol®, and Hyaluronic Acid in a Isotonic form.
  • Studies suggest these ingredients may help support and maintain joint health and flexibility. These ingredients include:
    • Glucosamine – A building block of cartilage and joint tissue.
    • Pycnogenol® – Has been shown in studies to support joint comfort.
    • Hyaluronic Acid – Major component of joint synovial and cartilage.
  • Ideal for men and women with an active lifestyle and/or aging.
  • Glucosamine is not readily available from food sources, making supplementation ideal for glucosamine needs.
  • Pycnogenol® is highly bioavailable to the body, making it easily absorbed, according to studies.
  • Hyaluronic Acid may help import joint flexibility and is a major component of joint synovial fluid.
  • Easy-to-take, great tasting, Isotonic formula for anyone who has difficulty swallowing tablets.
  • This vegetarian, gluten free product contains no added wheat, soy, gluten, artificial flavours, salt, preservatives or milk. Offered with the fastest and most efficient delivery system of all nutraceuticals with Isotonix.
  • Produced to high GMP (Good Manufacturing Practises) quality standards.
  • Does not contain MSM or Chondroitin. Chondroitin has poor absorption due to its high molecular weight and has inconclusive research. Research on MSM is also inconclusive, and it take large quantities (2-6 grams) daily for effects to become noticeable.


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Product Classifications

Gluten-Free – The finished product contains no detectable gluten (<10ppm).

No Detectable GMOs – The finished product contains no detectable genetically-modified organism.

Vegetarian – Isotonix Prime Joint is a vegetarian product.

Isotonic-Capable Drinkable Supplements – easy-to-swallow supplements in liquid form are immediately available to the body for absorption.

Product Classifications  

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Why Choose Prime Joint by Isotonix?

As the body ages, many people experience joint discomfort. Market United Kingdom understands how important it is to stay active and happy, so one option is to take a joint supplement to help promote overall bone and joint health. It is critical when choosing a joint supplement to choose one that has the ingredients essential to joint health. Prime Joint Support Formula contains three, some of which aren’t readily available from food sources, making supplementation ideal to obtain the benefits found within them. 

When looking at a joint supplement, there is one main non-controversial ingredient found in most products on the market, glucosamine. The research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. Glucosamine is a component of glycosaminoglycan, a molecule used in the body in the production of cartilage and other body tissues. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. 

Hyaluronic Acid is a component of synovial fluid and cartilage in joints and is one of the main lubricating components. It is present in every tissue of the body. Although it is produced naturally by the body, the levels of hyaluronic acid diminishes with age, contributing to stiff and painful joints. Prime Joint Support Formula contains 25mg of Hyaluronic Acid to help support and maintain joint health and flexibility.

Contains Pycnogenol® (French maritime pine bark extract) which is the most clinically researched and potent bioflavonoid with more than 120 studies published in peer-reviewed medical journals. For more information visit:

Your body and joints deserve the best, and Isotonix Prime Joint Support Formula is the only product on the market delivering glucosamine, hyaluronic acid, and Pycnogenol® in Isotonic form. Take control of your joint health, and buy Isotonix Joint Support Formula now!

Why Choose Prime Joint by Isotonix?  

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Learn More

Isotonix Delivery System

Isotonix – The World’s Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients

Glucosamine (HCl): 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®): 25 mg
Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins.

Hyaluronic Acid (Sodium Hyaluronate): 25 mg 
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

Frequently Asked Questions

What is the recommended dosage?
Pour 2 level, white bottle capfuls of powder into a cup. Add 120 mL of (line on the over cap indicates 60 mL) of water and stir. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

What is Synovial Fluid and how does it contribute to Joint Health?
Synovial fluid is a thick, stringy fluid found in the cavities of synovial joints. It reduces friction between the articular cartilage and other tissues in joints by lubricating and cushioning them during movement. Synovial Fluid is made of Hyaluronic Acid and lubricin, proteinases, and collagenases. Synovial fluid aids in the nutrition of articular cartilage by acting as a transport medium for nutritional substances, such as glucose, and provides lubrication of the articulating surfaces.

What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula as omega III fatty acids have been shown to support healthy joint lubrication.

How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.

How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
There are 25 milligrams of Pycnogenol in each daily serving.

Who should not use this product?
If you are currently using warfarin (Coumadin®), other antiplatelet/anticoagulant medications, antihypertensive medications, or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have a known allergy to shellfish, do not use this product. Women who are pregnant or breastfeeding should not use this product.


  • Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
  • Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
  • Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
  • Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
  • Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
  • Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
  • Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
  • Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
  • Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
  • Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
  • Grimm T, Skrabala R, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Hogger P. Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers. BMC Clinical Pharmacology 2006; 6:4.
  • Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
  • Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
  • Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics. 40(4):158-168, 2002.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.


SHOP.COM Reviews

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on 23/3/2019

It makes me sad when I read about customers having such a difficult time pouring out the powder from the bottle. The person giving you this product is supposed to teach you how to take these products in an easy and convenient manner. There are two ways in which to use these powders: one is to prick a hole in the seal with a toothpick against one side of the rim of the bottle. That controls the amount of powder that comes out. Just tap the top of the mouth to get the flow of powder going. The second way is to have your distributor supply you with a plastic cap with a hole in the middle. As distributors, we can buy a package of these to give to our customers. If you are having difficulties, please get back to your distributor for help.

Response from Customer Service on 27/3/2019

These are great, time proven recommendations for easy pouring of Isotonix Powder. Not only can the SHOP Consultant assist with product support, but the Product Information Department (ph: 336.389.6987 or email is available to answer ANY questions on product or product usage.

In progress still deciding

by AutumnB

on 17/1/2019

Good tasting. Seems to be working. I was afraid to taste it but I did n said wow.

Difficult to measure


on 26/11/2018

I like the product but not the packaging. I have found it difficult to pour a capful to measure and often messy since the powder drifts when pouring, and it has only gotten worse as the bottle has gotten nearly empty. My 80year old mother has also had difficulties with it. Please consider putting in a jar with measuring scoop. This would apply to any of your products. I currently also use OPC3


by jeffreyW

on 9/11/2018

have been taking the product about 2 weeks and i am noticing improvement in my knees and hands. I will continue using daily until the container is empty and then evaluate.
thank you

Shoppers found this review helpful



on 8/10/2018

I love this product, has helped so much with my knees and back.