NR + Pterostilbene: The NAD Production Dream Team
Validated by research.
90%
increase of NAD levels in the blood after a double dose of NR and pterostilbene*
60%
Pterostilbene is 60% more bioavailable than its counterpart resveratrol.**
Prime NAD+ is formulated with two powerful ingredients, NR and pterostilbene, both of which have scientifically proven their ability to support cellular health.

Nicotinamide Riboside: Your Key to Promoting NAD
Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions to be converted into NAD. NAD is a critical coenzyme found in every cell of the body. It carries electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production — the energy source fueling various cellular functions.

Product Classification

Gluten-Free

Vegan

Non-GMO

Good Manufacturing Practices
Key Ingredients & Benefits

Nicotinamide Riboside
studied for its potential benefits in relation to the following:
supporting healthy NAD production
helping maintain neurological and cognitive health
supporting cellular health

Pterostilbene
studied for its antioxidant properties
helps to neutralise harmful free radicals and oxidative stress
Fountain of Youth
Unlock the secret to healthy ageing and vitality with Prime Anti-Aging Nutraceuticals NAD+. It's time to take control of your energy reserve and support a better you. Forget age; take back your vitality with Prime NAD+.
Frequently Asked Questions
What is the goal of Prime NAD+?
While all our Prime products are crafted to promote healthy ageing at every level, Prime NAD+ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD molecule to help support healthy ageing.
What are the two factors that play into the continuous replenishment of NAD in the cells?
The consumption and synthesis of NAD are two factors that play into the replenishment or concentration levels of NAD within the cells. There are three pathways that are responsible for helping to maintain this balance, with each working in different ways to help the precursor NR and other NAD precursors convert into NAD for the body’s cells.
How was NAD discovered?
NAD was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolise sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD and identified responsible enzymes. The pathway that converts nicotonic acid to NAD is named the Preiss-Handler pathway.
What can deplete NAD levels in the body other than ageing?
Regardless of age, rough lifestyle habits can contribute to the increased need of NAD. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD depletion.
Prime NAD+ Research Scope
30+
trillion cells in the body are fueled by the NAD module.
500+
The number of enzymatic reactions fueled by NAD
50%
The rate of loss of NAD by the age of 50
4x
Pterostilbene has a bioavailability of 80% compared to resveratrol's 20%
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
Product Label Details
Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
*Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
**Pterostilbene supplement benefits: Longevity miracle or hoax. https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/

Reviews
Customer Rating
5.0 out of 5 star rating.
(1 reviews)
would recommend this product.
- Newest
- Highest Rating
- Lowest Rating
- Oldest
- Most Helpful
I have been taking NAD+ for 2 months now and i have visibly reduced wrinkles on my forehead.
I cant believe just how much they have reduced and how much better my skin on my face is.
I'm looking younger and fresher through continuing to add these to my daily regimen.
I would highly recommend this product to anyone who is looking for a non invasive, no-needle based, collagen fix!!
Out of this world product for the healthy girl era!!
Share this page!
Copy this link and paste to your favorite social, blog or website.
Link copied! Please paste and share on your favorite platforms.
There was an error copying to your clipboard. Please try again later.