Unlock the secret to healthy ageing and vitality with Prime Anti-Aging Nutraceuticals NAD+. Just as atoms form the foundation of the universe, cells are the building blocks of our bodies, and at the core of cellular health lies nicotinamide adenine dinucleotide (NAD): an essential coenzyme for carrying out cellular and metabolic functions. Prime NAD+ harnesses the power of science to deliver 250 mg of nicotinamide riboside (NR) and 50 mg of the NAD precursor, pterostilbene, scientifically studied for their potential to support NAD levels within your cells. NAD may play a role in maintaining optimal cellular metabolism, energy production and youthful vigour. Whether you're combating age-related NAD decline or tackling the challenges of a demanding lifestyle, Prime NAD+ is your ally in sustaining a healthy reservoir of this vital molecule. It's time to take control of your energy reserve and support a better you. Forget age; take back your vitality with Prime NAD+.

Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its ageing process: nicotinamide adenine dinucleotide (NAD). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD and its metabolic counterpart NADH are what the cell relies on for life. 

These compounds hold the key to supporting healthy metabolism and ageing. NAD is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of adenosine triphosphate (ATP) production within the cells, supporting the body’s cellular regeneration process and supporting healthy mitochondrial metabolism. Prime Anti-Aging Nutraceuticals NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been studied for their potential to support NAD levels within our cells. Prime NAD+ is a time-free, non-GMO, cutting-edge formula with ingredients that may support healthy NAD production and maintain NAD levels in ageing adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD. Whether you are looking to combat the natural age-related decline of NAD levels or support NAD levels for those living NAD-depleting lifestyles, the ultimate goal of Prime NAD+ is helping you sustain a healthy reservoir of the youthful NAD molecule. 

NAD is naturally occurring; it resides in every living cell in the body and its link to keeping one's youth has been studied. Various sources of vitamin B3 are known as precursors of NAD+, meaning they influence or help build upon the production of NAD.The balance between the consumption and synthesis of NAD plays into the replenishment or concentration levels of NAD within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD precursors into NAD for our cells. Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway, which plays a unique role in restoring the pools of NAD in our cells.NAD+, the oxidised form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD+/NADH redox ratio, which provides insight as to how well our cells are creating energy (ATP) and portrays the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio by throwing it off balance, and imbalances of this ratio are associated with cellular ageing. Studies suggest that consuming more NAD precursors that promote the increase of NAD may contribute to helping to maintain a healthy balance of this ratio. 

Younger people naturally have higher levels of NAD pools in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of ageing as their age group are also correlated with higher pools of NAD. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD production begins to first decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD levels.Other cellular pools (such as mitochondria, adipose tissue and muscle) are also impacted by age and the loss of NAD, emphasising that NAD may play a crucial role in healthy ageing. 

Prime NAD+ is formulated with two powerful ingredients, NR and pterostilbene, both of which have been studied for their potential ability to support cellular health. A study analysing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase in NAD levels. When analysing concentration of NAD levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group who was administered a double serving showed a 90% increase of NAD levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days. 

While supplementation of NAD precursors may help to achieve an extra reserve of NAD, it is NAD itself that really does the heavy lifting and influences all the different working parts of the cell that support cellular health. One influencing factor is the promotion of sirtuins (SIRTs) activity, also known as the ''longevity genes.'' These genes are enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. Prime NAD+ helps support the normal activity of the SIRT-1 gene, which protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-ageing pathways, longevity and the modulation of a number of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. 

While maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomeres. Telomeres are genome-protective caps located at the end of chromosomes: They act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying. These little caps can indicate the age or suggested lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomeres become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Shorter telomeres appear to be associated with lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age, and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process.Studies suggest that taking both NR and pterostilbene together can support the ability of each to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene is an autophagy-influencing antioxidant that supports the mediation of SIRT-1 and SIRT-2, which may help maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91-minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period. 

Regardless of age, practising poor lifestyle habits such as smoking, drinking alcohol, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD, making NAD-promoting supplementation potentially beneficial for adults, even those who are younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene offer a treasure trove of benefits for our overall well-being and may bring you one step further to helping you hack the ageing process. With Prime NAD+ on your side, ''The golden age is before us, not behind us.'' You don’t have to wait until you are aged to start caring about ageing. 

*This product is not intended to diagnose, treat, cure, or prevent any disease.

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Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the ageing process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying elections between molecules in essential steps for many metabolic processes within the cell, namely ATP production — the energy source fueling various cellular functions. 

Pterostilbene 
Pterostilbene is a naturally occurring compound synthesised in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been studied for its antioxidant properties, helping to neutralise harmful free radicals and oxidative stress.

1. What are the directions of use for this product?
   For adults, take 2 capsules every morning with or without food. Do not exceed the recommended daily dose. 
   
   
2. Are there any warnings for this product?
   If you are currently using prescription drugs or if you have an ongoing medical condition, consult your health care provider before using this product. If you are pregnant or breastfeeding, do not use this product. 
   
   Store out of the reach of young children. Store in a cool, dry place. Do not use if safety seal is broken or missing. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. 
   
   
3. What are the two factors that play into the continuous replenishment of NAD in the cells?
   The consumption and synthesis of NAD are two factors that play into the replenishment or concentration levels of NAD within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD precursors convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway. 
   
   
4. What is NAD+/NADH redox ratio?
   NAD+ is recognised as the oxidised form of nicotinamide adenine dinucleotides, whereas NADH is the reduced form. Overall, the NAD+/NADH redox ratio explains how well the cells are creating energy or ATP, portraying the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance and leading to a decreased ratio which is also associated with age. Consuming more NAD precursors that help support levels of NAD may be effective for helping to maintain a healthy balance of this ratio.
   
   
5. What can deplete NAD levels in the body other than ageing?
   Regardless of age, rough lifestyle habits can contribute to the increased need of NAD. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD depletion.
   
   
6. Is this product vegetarian or vegan?
   This product contains no animal-derived ingredients and is suitable for vegetarians and vegans. 
   
   
7. What are NAD precursors?
   Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN) and tryptophan (Trp), are known as precursors of NAD, meaning they influence or help build upon the production of NAD. 
   
   
8. What is the half-life of pterostilbene in comparison to resveratrol?
   Pterostilbene has a much longer half-life (105 minutes) than resveratrol (14 minutes), meaning that pterostilbene is actively working in your system for a longer time. 
   
   
9. What are other ways you can promote sirtuin activity?
   Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, resveratrol and curcumin may also help promote sirtuin activity. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins. 
   
   
10. What are telomeres?
    Telomeres are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomere in length, the better. Telomeres are like the clear coating at the end of the shoelace string that keeps the lace from fraying; each time your cells divide, the chromosomal telomeres become shorter. Whereas maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomeres. Shorter telomeres appear to be associated with lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age, and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process. 
    
    
11. What is the goal of Prime NAD+?
    While all our Prime products are crafted to promote healthy ageing at every level, Prime NAD+ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD molecule to help suppot healthy ageing. 
    
    
12. What foods contain NAD precursors or naturally assist in promoting NAD?
    Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD levels. 
    
    
13. How was NAD discovered?
    NAD was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolise sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD and identified responsible enzymes. The pathway that converts nicotonic acid to NAD is named the Preiss-Handler pathway.
    
    

*This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

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