Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Vegan - This product is vegan

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Grape Seed Extract (25 mg) 
Grape seed extract is typically extracted from the seeds of red grapes, which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to help maintain cardiovascular health.

Red Wine Extract (25 mg) 
Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation and overall cardiovascular health.

In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for the cardiovascular health.

Pine Bark Extract (Pycnogenol®) (25 mg) 
Pycnogenol is a natural plant extract from the bark of specific maritime pine trees grown exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

As a potent antioxidant, Pycnogenol combats oxidative stress. Its super-antioxidant capabilities help support healthy blood glucose levels, maintain joint flexibility and help to promote maintenance of cardiovascular health.

Bilberry Extract (25 mg)
Bilberry extract is derived from the berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies suggest that bilberry extracts may help support visual and cardiovascular health.

Citrus Extract (Bioflavonoids) (25 mg) 
Citurs bioflavonoids are plant compounds that act as light filters and pigments in the plants. These bioflavonoids are also known for their antioxidant properties. They have been found to help maintain cardiovascular health.

What is Isotonix OPC-3®? 
Isotonix OPC-3 is a dietary supplement that bears some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs chosen for OPC-3 are prepared from grape seed, red wine, bilberries, Pycnogenol from pine bark and citrus fruit. This combination of powerful OPCs is unique to OPC-3, as is the Isotonix® delivery system, which enables rapid and highly efficient absorption of the OPCs. Numerous scientific studies have shown that ingredients found in OPC - 3 may contribute to the maintenance of cardiovascular health, joint health and flexibility, visual health, immune health, blood pressure, antioxidant protection, and blood glucose levels. 

What are the directions for use? 

Directions for Use: For Children Ages 2 – 3 years: Pour ½ white bottle capful of powder (1.65 grams) into the overcap. Add water half-way to the line on the overcap (30 mL) and stir. For Adults and Children 4 years and older: Pour 1 level, white bottle capful of powder (3.3 grams) into the overcap. Add water to the line on the overcap (60 mL) and stir. For Adults: For best results take 2 capfuls per 68.2 kg of body weight daily for the first 7-10 days, and take 1 capful thereafter as a maintenance programme. As a food supplement take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used. 

Why should everyone take Isotonix OPC-3?

Everyone is subject to free radical damage and oxidative stress. Free radicals develop as byproducts of physiological processes that occur within the body. This damage does not cause noticeable harm at first, yet may add up over the years.OPCs are some of the most powerful natural free radical neutralizers and you get the best of all OPCs by taking Isotonix OPC-3. Regular use every day is vital for keeping free radicals in check and a long, healthy life.

Why is Isotonix OPC-3 great for my children?

Our formula is a delicious, easy-to-take, once a day formula for the entire family to enjoy, especially for fussy children. It is also ideal for anyone who wants key ingredients like Pycnogenol®, grape seed and other extracts and for everyone who has difficulty swallowing capsules or tablets. The research behind Pycnogenol® is amazing for both children and adults, having more than 120 studies published in peer-reviewed medical journals.* For parents, you will love that our formula contains no artificial flavours or colouring, and it’s a vegetarian product that also contains no added wheat, soy, yeast, gluten, salt, preservatives or milk (lactose) for your children. It is also offered with the fastest and most efficient Isotonix delivery system so nutrients maybe delivered into their bodies fast and efficiently. You can also be assured that our product is produced to high GMP, Good Manufacturing Practises, quality standards.

* For more information visit: www.pycnogenol.com/applications

Can my children take OPC-3 in addition to other Isotonix products?
Yes, some other Isotonix products –Isotonix Digestive Enzymes and Isotonix Multivitamin– can be taken in addition to Isotonix OPC-3. Also, children can take their Isotonix products at the same time like adults already do, as long as they are mixed using the proper ratios as per the directions to keep it isotonic.

Are there any allergens in Isotonix OPC-3?
Isotonix OPC-3 is a vegetarian product and contains no added wheat, soy, yeast, gluten, artificial flavour, salt, preservatives or milk (lactose).

Is there any research on children and the benefits of Pycnogenol?

Yes. A small pilot study showed that supplementation with Pycnogenol® (2 mg/kg of body weight) for 10 weeks can improve markers of oxidative stress in children (13 – 18 years of age) with Crohn’s disease (Kolacek et al., 2013). Supplementation of Pycnogenol® (1 mg/kg of body weight) helped reduce hyperactivity and improve attention in children (6 – 14 years of age) with Attention Deficit/Hyperactivity Disorder (ADHD) (Trebaticka et al., 2006). Studies have also shown that Pycnogenol® supplementation (1 mg/kg of body weight) for 1 month can help reduce oxidative stress, improve total antioxidant status, and improve attention in children (6 – 14 years of age) with ADHD (Chovanova et al., 2006; Dvorakova et al., 2006, 2007). Furthermore, supplementation with Pycnogenol® (1 mg/lb of body weight) by asthmatic children (6 – 18 years of age) may help reduce signs of asthma and reduce the frequency of use of asthma inhalers (Lau et al., 2004). These claims have not been approved by the European Commission.

What sets Isotonix OPC-3 apart from other bioflavonoid products?
The science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The potent nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful free radical scavenging product available.

Is Isotonix OPC-3 safe?
Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. OPC-3 contains pure OPCs in combination with carefully balanced quantities of potassium and fructose/glucose, which set up the isotonic delivery system. OPC-3 is free of harmful chemicals, preservatives and alcohol. OPC-3 should be taken as directed.

How long does it take to benefit from Isotonix OPC-3?

OPC-3 not only provides the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine rapidly absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. The liquid is isotonic, which means it duplicates the environment in our cells and blood stream regarding pH, electrolytes, etc. This enables the OPCs to enter the body easily and with a high level of bioavailability. Because of the rapid absorbability, the body should benefit from Isotonix OPC-3 almost immediately.

Can you take Isotonix OPC-3 in soda, juice, coffee, etc., rather than water?

It is possible but not recommended. This product should only be taken as directed. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. Mixing the products with anything else besides other Isotonix products and water slows down the delivery time and may affect the percentage of uptake.

I am healthy and athletic, why should I take Isotonix OPC-3?

Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as by-products during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. The antioxidant and circulatory benefits of OPCs may therefore be a benefit to athletes.

Can you tell me more about Pycnogenol®?

Pycnogenol is the registered trademark of Horphag Research (UK) for a standardised extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids in Pycnogenol not only acts as powerful antioxidants, they also appear to promote the normal generation of nitric oxide (NO), which plays a key role in cardiovascular health.

Does OPC-3 have visible benefits? 
Pycnogenol has been reported to help support healthy skin collagen, help the skin feel smoother and more supple, and maintain a healthy skin tone. Additionally, it has been suggested that Pycnogenol may help protect the skin from the photo-aging effects of the sun. These benefits may help support a visibly healthy complexion. However, it requires patience to show visible effects.

Does OPC-3 have benefits specifically for women? 
Some OPCs were shown in clinical trials to help women who suffer from menstrual discomfort. When women were supplemented with OPCs, starting at least a week before their menstrual period, menstrual discomfort was significantly eased.

How can OPC-3 help my eyes? . Isotonix OPC-3 contains specific OPCs that have been successfully tested for its contribution to eye health. Pycnogenol has been shown to support healthy circulation in the eye. Therefore, Isotonix OPC-3 may help contribute to the maintenance of visual health.

What is the history of OPCs?

In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.

Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.

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