Isotonix Vitamin D3 with K2

(87)
Isotonix Vitamin D3 with K2

Roll over image to zoom

  • View Larger Image
  • View Larger Image
  • Single Bottle (30 Servings)
  • Label

Sold by Isotonix®

£24.75

This product qualifies for free shipping. Learn More

Free shipping

All Market United Kingdom products qualify for Free Shipping. Conditions apply, see details.



Single Bottle (30 Servings)

Add to AutoShip and never run out again!

Notify when the price is less than or equal to:

Price entered must be less than the current product price and greater than zero.

Your email address:

You already have an active alert for this item.

This product has been saved

Isotonix Vitamin D3 with K2

Sale £24.75

$productContainer.cashBack.cashBackString.getTextValue()  Cashback  

We've successfully added your item!


This item has been added to

This item has been added to

Thanks! We'll email you if the price drops to your target price or lower. The alert will be in effect for 60 days.


To extend this price watch, create additional price watches, or to otherwise manage your alerts, please follow the instructions contained in the email that has been sent to the address you provided.

We've successfully added your egift!

This item has been added to

This item has been added to

This item has been added to



Product Information

Contributes to:

  • Normal absorption and utilisation of calcium and phosphorus
  • Normal blood calcium levels
  • The maintenance of normal bones, normal muscle function and normal teeth
  • Normal function of the immune system
  • The process of cell division
  • Normal blood clotting

Product Information

Isotonix Vitamin D3 with K2

Isotonix Vitamin D3 with K2 contains vitamin D3, the metabolically active form of Vitamin D, along with Vitamin K2, which supports normal blood clotting and bone health. Isotonix Vitamin D3 with K2 is the first of its kind to combine both of these powerful vitamins with isotonic delivery, helping to maintain normal bones, muscle function and teeth. In addition, these vitamins work together to maintain the body’s normal absorption of calcium and phosphorus, as well as contribute to the normal function of the immune system, and the process of cell division.

Vitamins D3 and K2 are paired together in Isotonix Vitamin D3 with K2, because they work synergistically to support normal bone health. Two of the more common forms of vitamin K are K1 and K2. While there are many similarities between these two forms of vitamin K, they can be distinguished by their important differences, the most significant being their differing pharmacokinetic properties. Vitamin K1 disappears rapidly from the blood, while vitamin K2 persists in the blood’s circulation for a longer time.

REVIEW SNAPSHOT®

by PowerReviews
Isotonix® Vitamin D with K2
 
4.6

(based on 87 reviews)

Ratings Distribution

  • 5 Stars

     

    (62)

  • 4 Stars

     

    (18)

  • 3 Stars

     

    (4)

  • 2 Stars

     

    (2)

  • 1 Stars

     

    (1)

96%

of respondents would recommend this to a friend.

Pros

  • No side effects (40)
  • Good value (30)
  • Works quickly (27)
  • Natural-feeling results (24)
  • Relieves stress (10)

Cons

    Best Uses

    • Morning (35)
    • Daily use (27)
    • Afternoon (5)
    • Before sleep (5)
      • Reviewer Profile:
      • First time user (30), Regular user (27), Health conscious (18), Medical professional (3)

    Reviewed by 87 customers

    Sort by

    Displaying reviews 1-5

    Back to top

    Previous | Next »

     
    5.0

    Love the taste

    By Sheba

    from Rochester, New York

    Pros

    • Easy To Take
    • Tastes Good

    Cons

    • Day Size
    • I Wish That You Offered A
    • Larger Sized Bottle-90

    Best Uses

    • Everyday Use

    Comments about Isotonix® Vitamin D with K2:

    I take it first thing in the mornings that I do not plan to be in the sun. I live in an area that is cloudy for much of the winter & and often in the spring and fall, too.

    (1 of 1 customers found this review helpful)

     
    5.0

    Re: "Wasted 1/4 of Product"

    By Yana and KenR

    from USA

    SHOP CONSULTANT

    Comments about Isotonix® Vitamin D with K2:

    Maria, I hope that you read this! The "Cap" that you measure the powder into is NOT the cap that you fill with water! Your product should have come with an "overcap" that is used to measure the right amound of water (2 ounces) for every bottlecap of powder. THAT cap is the one that is right on the bottle. If you use them correctly, you should not have water getting into the bottle. That having been said, if you live in a humid environment, you can actually just refrigerate the bottle to make sure that it stays fresh and dry.

     
    2.0

    Wasted 1/4 of Product

    By MariaS

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Somehow water got inside the bottle and wasted the 1/4 of remaining powder. I think a different mechanism is needed, since the bottle top is used to administer the product with water. I'm going to try again and use without the bottle top to see if it makes a difference.

    (0 of 1 customers found this review helpful)

     
    5.0

    Tastes great!

    By DanielP

    from USA

    Comments about Isotonix® Vitamin D with K2:

    Tastes like kool aid and boosts immunity while protecting against a myraid of afflictions. Everyone needs Vit D and this is the best!

     
    4.0

    very good

    By pat

    from seffner fl.

    Verified Buyer

    Comments about Isotonix® Vitamin D with K2:

    its so easy to takee

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    Ingredients

    Vitamin D3 (Cholecalciferol)
    Vitamin D is a fat-soluble vitamin that occurs naturally in some foods like fish and eggs and is present in fortified foods such as milk and orange juice. Vitamin D is also produced by the body when sunlight strikes the skin, activating Vitamin D synthesis. Vitamin D promotes the efficient absorption of calcium and promotes the normal formation, growth and remodelling of bone.

    Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of Vitamin D. Factors contributing to Vitamin D deficiency increase with age. Deficiency has been linked to numerous health concerns; insufficient levels of this vitamin are associated with frail bones and muscle weakness.

    Vitamin K2
    Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although it is a fat-soluble vitamin, the body stores very little vitamin K at any given time and without regular dietary intake the body’s store of Vitamin K can be rapidly depleted. Natural vitamin K2, also known as menaquinone-7 (MK-7), appears to be more bioavailable and has a longer half-life in the blood than vitamin K1. The Japanese soy-based food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health.

    Science

    • Argiles A et al.  Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients.  Blood Purification.  20(4):370-375, 2002.
    • Bekner K.  The vitamin K-dependent carboxylase.  Journal of Nutrition.  130(8):1877-1880, 2000.
    • Binkley N et al.  Vitamin K nutrition and osteoporosis. Journal of Nutrition.  125(7):1812-1821, 1995.
    • Bischoff-Ferrari Het al.  Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.  JAMA. 293(18):2257-2264, 2005.
    • Buitenhuis HC, Soute BAM, Vermeer C.  Comparison of the vitamins K1, K2, and K3 as cofactors for hepatic vitamin K-dependent carboxylase.  Biochem Biophys Acta 1990; 1034:170-175.
    • Chapuy M et al.  Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
    • Garber, A. K., et al.  Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects.  Journal of Nutrition.  129(6):1201-1203, 1999.
    • Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
    • Guirguis-Blake J et al.  Oral vitamin D3 decreases fracture risk in the elderly.  Journal of Family Practice.  52(6):431-435, 2003.
    • Gundberg C et al.  Vitamin K status and bone health:  an analysis of methods for determination under carboxylated osteocalcin. Journal of Clinical Endocrinology and Metabolism.  83(9):3258-3266, 1998.
    • Hidaka T et al.  Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2).  Journal of Bone and Mineral Metabolism.  20(4):235-239, 2002.
    • Hiruma Y et al.  Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. Biochemical Biophysical Research Communications.  314(1):24-30, 2004.
    • Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review.
    • Iwamoto J et al.  Effects of vitamin K2 on osteoporosis.  Current Pharmaceutical Design.  10(21):2557-2576, 2004.
    • Kameda T et al.  Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.  Biochemical and Biophysical Research Communications.  220(3):515-519, 1996.
    • Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007.
    • Kristal-Boneh E et al.  Association of calcitriol and blood pressure in normotensive men.  Hypertension.  30(5):1289-1294, 1997.
    • Li Y et al.  1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.  Journal of Clinical Investigation.  110(2):229-238, 2002.
    • Li Y et al.  Vitamin D regulation of the renin-angiotensin system.  Journal of Cell Biochemistry.  88(2):327-331, 2003.
    • Li Y et al.  Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.  Journal of Steroid Biochemistry and Molecular Biology.  89-90(1-5):387-392, 2004.
    • Nelsestuen G et al.  Vitamin K-dependent proteins.  Vitamins and Hormones.  58:355-389, 2000.
    • Neogi, T., et al.  Low vitamin K status is associated with osteoarthritis in the hand and knee.  Arthritis and Rheumatism. 54(4):1255-1261, 2006.
    • Pfeifer M et al.  Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.  Journal of Clinical Endocrinology and Metabolism.  86(4):1633-1637, 2001.
    • Plaza S and Lamson D. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Reviews. 10(1):24-35, 2005. Review.
    • Price P.  Role of vitamin K-dependent proteins in bone metabolism.  Annual Review of Nutrition.  8:565-583, 1988.
    • Schaafsma, A., et al.  Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities:  effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin.  European Journal of Clinical Nutrition.  54:626-631, 2000.
    • Schleithoff S et al.  Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.  American Journal of Clinical Nutrition. 83(4):754-759, 2006.
    • Shearer M.  Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.  Current Opinion in Clinical Nutrition and Metabolic Care.  3(6):433-438, 2000.
    • Shearer MJ, Newman P.  Metabolism and cell biology of vitamin K. Thromb Haemost 2008; 100:530-547.
    • Shiraki, M., et al.  Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.  Journal of Bone & Mineral Research.  15:515-522, 2000.
    • Schurgers LJ, Teunissen KJF, Hamulyak K, Knapen MHJ, Vik H, Vermeer C.  Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menquinone-7.  Blood 2007; 109:3279-3283.
    • Sigmund C.  Regulation of renin expression and blood pressure by vitamin D (3).  Journal of Clinical Investigation.  110(2):155-156, 2002.
    • Taira H et al.  Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.  Calcified Tissue International. 73(1):78-85, 2003.
    • Trivedi Det al.  Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.  British Medical Journal.  326(7387):469, 2003.
    • Van den Berghe G et al.  Bone turnover in prolonged critical illness: effect of vitamin D.  Journal of Clinical Endocrinology and Metabolism.  88(10):4623-4632, 2003.
    • Vasquez A et al.  The clinical importance of vitamin D (cholecalciferol):  a paradigm shift with implications for all healthcare providers.  Alternative Therapies.  10(5):28-38, 2004.
    • Weber P.  Management of osteoporosis: is there a role for vitamin K?  International Journal for Vitamin and Nutrition Research. 67(5):350-6, 1997.
    • Yokoyama T et al.  Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines.  International Journal of Oncology.  26(1):33-40, 2005.
    • Zitterman A et al.  Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?  Journal of the American College of Cardiology.  41(1):105-112, 2003.

    FAQ

    Why are vitamins K and D included in Isotonix Vitamin D3 with K2?
    Vitamins K and D work together to support the maintenance of normal bones. Vitamin D also contributes to the maintenance of normal muscle function and normal functioning of the immune system.
     
    Is Isotonix Vitamin D3 with K2 safe for people on anti-coagulant medications?
    Some studies have suggested that vitamin K2 does not interfere with anticoagulant medications. However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to use the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
     
    How do I take Isotonix Vitamin D3 with K2?
    Pour 1 level bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl. oz./60 ml) and stir. Take once daily or as directed by your healthcare provider.  Maximum absorption occurs when taken with a meal. This product is isotonic only if the specified amounts of powder and water are used.
     
    Is it safe to take more than 1 serving of this product daily?
    One serving daily of Isotonix Vitamin D3 with K2 is recommended. Check with your healthcare provider before taking additional daily servings of this product.
     
    Is there a toxicity level for vitamin D?
    The recommended daily tolerable upper intake limit for vitamin D is 2,000 IU. If you wish to take more than one daily serving of this product, you should check with your physician.
     
    What are dietary sources of vitamin D?
    Foods naturally rich in Vitamin D include cod liver oil, salmon, mackerel, tuna and eggs.